A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.

Nat Commun · 2023 · PMC10325989 · PMID 37414772

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showed a trendno p-value reported

This analysis indicated that distal elements within TADs spanning DEGs identified in either of the two mutants showed a trend toward higher regulatory scores than genes whose expression was not altered (based on both the total number and individual strength of the sites contacted by PBX1 and/or HAND2 within the TAD; see Methods).

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