Association of Risk Variants in the CFH Gene With Elevated Levels of Coagulation and Complement Factors in Idiopathic Multifocal Choroiditis.

JAMA Ophthalmol · 2023 · PMC10326733 · PMID 37410486

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did not reach statistical significanceP = 3.0 × 10 −8actually significant

The risk allele G of rs7535263 was also more frequent in cases (allele frequency, 64 of 104 [62%]) of cohort 2 compared with controls (allele frequency, 1451 of 2584 [56%]) but did not reach statistical significance, most likely representing an underpowered comparison (combined meta-analysis (OR, 0.58; 95% CI, 0.38-0.77; P = 3.0 × 10 −8 ) ( Figure 4 ).

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