Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.

Although the number of neurons in the entorhinal/perirhinal cortex area had a fair amount of animal-to-animal variability, in some cases the number of AT8- and pS422-positive cells in the peri-/entorhinal of the HMW tau-injected group 3 months after injection were noticeably higher than that of PBS- or even SARK-injected animals, although a difference between the latter did not reach statistical significance (Fig. 3 c, e).

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