The reduction in CCL2 secretion did not reach statistical significance in CB2 -/- microglia (p (WT) = 0.0218, p (CB2 -/- ) = 0.5363), likely due to their generally lower CCL2 secretion capacity (Fig. 2 D).
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Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation.
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