Distinct hemodynamic and functional connectivity features of fatigue in clinically isolated syndrome and multiple sclerosis: accounting for the confounding effect of concurrent depression symptoms.

In the RR-MS group, severity of fatigue, after controlling for depression symptoms, was associated with heightened role of the left amygdala within the entire brain network (indicated by a marginally significant positive association of betweenness centrality of this region with fatigue ratings: r =.561, p =.002).

also in 26,082 other papers

Compared to the healthy controls, the subgroup of potentially depressed RR-MS patients displayed marginally greater proportion of voxels with hemodynamic delay coupled with hypoconnectivity ( p =.03), whereas the difference between depressed and non-depressed RR-MS patients approached significance ( p =.08).

also in 8,237 other papers