Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.

J Biol Chem · 2023 · PMC10339064 · PMID 37286039

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0.1300

closest p · 2.6× alpha

0.1300

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The sentences

did not reach statistical significancep = 0.13not close (p > 0.1)

Indeed, genetic deletion of CtBP2 in the liver increased the expression of PPARα target genes (1.2 ∼ 1.4-fold increase), reflecting the liberation of PPARα from CtBP2-mediated repression, although the difference did not reach statistical significance for Cpt1a gene ( p = 0.13) ( Figs. 5 A and S4 ).

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