Although the deviation from dose proportionality did not reach statistical significance, the increase in exposure appeared to be more than dose proportional in the 100 to 200 mg b.i.d. dose range, indicating the potential for nonlinear PK characteristics in the higher doses.
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Safety, tolerability, pharmacokinetic/pharmacodynamic characteristics of bersiporocin, a novel prolyl-tRNA synthetase inhibitor, in healthy subjects.
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