Lung Cancer Screening with Low-Dose CT: What We Have Learned in Two Decades of ITALUNG and What Is Yet to Be Addressed.

Outcomes Despite a LC mortality decrease of 30% after 9.3 years and of 24% after 11.3 years of follow-up [ 43 , 49 ] in subjects of ITALUNG undergoing LDCT, the differences with the LC mortality in the control arm did not reach statistical significance, presumably, because of the small sample sizes.

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