The Relationship between Telomere Length and Nucleoplasmic Bridges and Severity of Disease in Prostate Cancer Patients.

In PC patients with a Gleason score of > 7, the inverse correlation was highly significant between baseline or radiation-induced NPB frequency with TL (r = −0.404; p = 0.008; r = −0.403; p = 0.008, respectively; Figure 3 E,F).

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However, the frequency of NPBs shows an increasing trend with increasing GS ( p = 0.04; p trend = 0.01; Figure 2 B).

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Furthermore, TL was significantly shorter ( p = 0.03) in patients with a Gleason score more than 7 and there was also a significant trend of decreasing TL across all three stages ( p trend = 0.01; Gleason score <7, 7 and >7).

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