The Relationship between All-Cause Natural Mortality and Copy Number of Mitochondrial DNA in a 15-Year Follow-Up Study.

The GWA of mtDNA-CN based on CHARGE Consortium and UK Biobank cohorts ( n = 24,622; median follow-up 4318 days) found a nominally significant association between mtDNA haplotypes and the overall non-external mortality ( p = 0.044) [ 31 ].

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Similarly, in fully adjusted Model 3, the association remained modestly significant, the OR was 1.06 (95% CI 1.01–1.11) regardless of age, sex, smoking, systolic BP (SBP), total cholesterol (TC), TG, FPG or DM2, BMI or WHR, education and alcohol intake ( Table 2 ).

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