The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment.

Int J Mol Sci · 2023 · PMC10341493 · PMID 37445994

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A substantial level of expression of TG2 mRNA was found, with a clear trend to increase once the organoid epithelium was differentiated towards mature villous epithelium by adding the ELR1 culture medium ( Figure 5 B).

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