H661 cells had a significant decrease in their cellular viability following a combination treatment with SHPi + refametinib (S + R) of 42.26 ± 13.13% ( p = 0.0341) compared to the vehicle control (VC), and although it was not significant, showed a trend of increased sensitivity compared to refametinib alone (31.86 ± 7.74%).
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RETRACTED: Protein Tyrosine Phosphatase Non-Receptor 11 (<i>PTPN11</i>/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC).
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