Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli.

PLoS Pathog · 2023 · PMC10348564 · PMID 37450466

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Finally, comparison of lung lesions in mice that were infected with phoPR-STB-K or phoPR-H37Rv complemented strains showed a trend for both a higher number and size of inflammatory lesions in the phoPR-H37Rv complemented group (Figs 5C and 5D and S11 ).

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