Utility of <i>Borrelia</i>-specific IgM and IgG antibody titer determinations during a 12-year period - results from a clinical laboratory in Northern Sweden.

By analyzing the annual data, it was observed that the group IgM positive/IgG negative demonstrated a significant quadratic time trend, i.e ., an increasing trend followed by a decrease ( Figure 2B ), whereas the other two groups fitted a linear model ( Figures 2C, D ).

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Interestingly, there was a clear trend of an increasing number of positive samples, since the peak number of positive IgG and/or positive IgM samples was observed during the period 2015-2017.

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