Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.

We also observed a marginally significant reduction in NC monocytes expressed as a percentage of all monocytes ( p = 0.05; Fig. 9 C; lower left).

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C3AR1 expression, as measured by ddPCR of PBMC RNA, trended toward reduction but did not achieve significance (Fig. 8 C).

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Intermediate monocytes (characterized by high CD14 levels and moderate-to-high CD16 levels) showed a trend toward reduced abundance, relative to either all PBMCs or all monocytes, but this difference did not reach significance (Fig. 9 C, middle panels).

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