Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 2: bone marrow-derived cell-based injectable therapies.

Despite the recent growing interest towards other MSCs sources showing more promising features in terms of results and availability, this systematic review showed that the research on bone marrow-derived products continues to be active, with an increasing trend in publications of preclinical animal studies on this topic observed over the years.

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The evaluation of risk of bias over time did not show a significant trend towards improving the quality of the included studies, with low-risk items reported in 44% vs 38% in the most recent half of the papers vs the older ones.

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