Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons.

Nat Commun · 2023 · PMC10356901 · PMID 37468558

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Additionally, SHLP2 improved glucose tolerance and exhibited a strong trend towards increasing insulin sensitivity (Fig. 4i, j and Supplementary Fig. 4g, h ).

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