Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity.

While the Region × Threat Certainty interaction was only marginally significant ( p = 0.10), focal comparisons indicated that that the Ce showed an indiscriminate pattern of reactivity, with statistically indistinguishable levels of heightened activation during the anticipation of certain and uncertain threat.

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