Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD.

156 A second study of 10-hour TRE for 12 weeks in patients with metabolic syndrome was also associated with a 10% reduction in both AST and ALT, although this did not reach statistical significance (p=0.09). 147 Further dedicated trials incorporating liver-specific outcomes are required in well-phenotyped patients with NAFLD/NASH in order to establish efficacy and decipher underlying mechanistic pathways contributing to improved liver and metabolic health.

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