Conversely, SYF-Src90F fibroblasts showed a trend towards reduced signalling through Ras/MAPK, PI3K/Akt, and Stat3 compared to SYF-c-Src cells, although the difference was not statistically significant ( Figure 5D ).
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Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase.
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