Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease.

Notably, however, and in contrast to PGG, Dox also reduced LVSP and showed a trend to further increase LV hypertrophy, findings that are in line with previous reports that Dox aggravates cardiac hypertrophy and dysfunction in mice with aortic constriction 74 .

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The latter finding was associated with a distinct decrease in all larger particle classes ( > 10 μm3); however, the difference failed to reach significance for each individual class.

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