Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.

Transl Psychiatry · 2023 · PMC10363543 · PMID 37482560

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

did not reach statistical significancep = 0.055so close (0.05 < p ≤ 0.1)

There was a similar trend between groups B (−0.24 [3.03]) and C (placebo) (−2.0 [2.58]) but this difference did not reach statistical significance ( p = 0.055).

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