Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine.

The incubation of PPAT supernatant with prostatic strips from lean mice caused a 2.8-fold rightward shift although this did not reach statistical significance (pEC 50 : 6.43 ± 0.30 vs. 5.98 ± 0.33 and E max : 1.64 ± 0.59 and 1.25 ± 0.53 mN/mg, in the absence and presence of PPAT, respectively, n = five to seven, p > 0.05) ( Figure 5A ).

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