Thermoneutral housing promotes hepatic steatosis in standard diet-fed C57BL/6N mice, with a less pronounced effect on NAFLD progression upon high-fat feeding.

Although there was a nonsignificant trend toward an increase in the lobular inflammation scores in HFD-fed mice under TN conditions (vs.

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mainly Kupffer cells) were quantified, including those located outside the hCLS structures, their total number did not change between groups; however, mice fed STD under RT conditions showed a trend toward decreased macrophage numbers compared with the other groups ( Supplementary Figure 3 ).

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