Barely Significant
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MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan.

Aging (Albany NY) · 2023 · PMC10373962 · PMID 37432063

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A facilitation of LTP was seen after enrichment in MSK1 KD mice but failed to reach statistical significance above that of the standard-housed MSK1 KD mice.

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highly significantno p-value reported
A more detailed between factors statistical analysis showed that, while there was no significant genotype x housing interaction, the difference between enriched WT and MSK1 KD mice was highly significant indicating that enrichment benefited WT mice more than the MSK1 KD mutants in this test of cognitive flexibility.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.