DNA Methylation Signatures of Response to Conventional Synthetic and Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis.

Epigenome-wide association study in PBMCs found nominally significant ( p < 0.05) DMPs between response groups but none at the genome-wide significance level.

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However, the increased number of probes from the EPIC array means that in statistical testing the p value threshold to pass FDR also increases and therefore probes that were statistically significant from the 450K array may not be significant when tested with all the probes from the EPIC array.

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