Corneal Outcomes Following Cataract Surgery Using Ophthalmic Viscosurgical Devices Composed of Chondroitin Sulfate-Hyaluronic Acid: A Systematic Review and Meta-Analysis.

The meta-analysis revealed that when compared against other OVDs, those containing CS-HA demonstrated significantly less increase in CT from baseline to 1 day postoperatively with the fixed effect model (MD: −1.47%; 95% CI: −1.89% to −1.05%; p < 0.0001; 6 studies) but did not reach statistical significance at the 5% level with the random effects model (MD: −2.02%; 95% CI: −4.24% to 0.18%; p = 0.07; 6 studies; Figure 4A ). 28 , 31 , 34 , 37–39 When compared to HA-only OVDs, CS-HA OVDs had statistically significantly less CT change with the random effects model (MD: −3.22%; 95% CI: −6.24% to −0.20%; p

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