Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents.

Pharmacotherapy · 2023 · PMC10378577 · PMID 36651686

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nearly significantno p-value reported

However, among individual SSRIs, this effect was nearly significant ( Relative risk: 1.06, CI: 1.00 to 1.13), and the effect was significant for escitalopram. 50 Additionally, neither SNRIs ( Relative risk: 0.97, CI: 0.88 to 1.06) nor second-generation antidepressants (e.g., bupropion, vilazodone, vortioxetine) were associated with a significant increase in headaches over the course of the trial.

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