Genotypic and Haplotypic Association of Catechol-<i>O</i>-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia.

Additionally, nominal association of COMT rs4818 polymorphism and scores on G1 item (corresponding to the intensity of somatic concern) was observed, where G allele was under-represented (19.3%) in male subjects with mild symptoms (R = −1.4; χ 2 = 4.186; p = 0.041) compared to C allele carriers (24.7%); however, after correction for multiple testing, this association did not reach statistical significance.

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