The UA showed better IPFS rates significantly related to male sex ( p = 0.049), a BED 12 of ≥42 Gy ( p = 0.006), and controlled extracranial disease ( p = 0.03); in the MA, a favorable trend towards LC ( p = 0.11) and higher BED ( p = 0.11) schedules maintained a correlation with improved IPFS rates, although statistical significance was not reached.
In agreement with the abovementioned studies, in our series, better LC rates were also found to be predictive of improved intracranial progression-free survival, although this did not reach statistical significance ( p = 0.11); nonetheless, this evidence supports the role of local treatments as an alternative strategy to delaying the administration of salvage whole brain radiotherapy or the initiation of new systemic agents.