Complexities in comparing the impact of costimulatory domains on approved CD19 CAR functionality.

J Transl Med · 2023 · PMC10387212 · PMID 37518011

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a clear trendno p-value reported

That being said, there is a clear trend in this analysis towards severe neurotoxicity events in patients treated with CARs utilizing the CD28 hinge and transmembrane domains.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.