Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics.

Cancer Res · 2023 · PMC10390863 · PMID 37145128

Europe PMC DOI

hedged sentences

0.0003

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantP = 0.00029actually significant

Eight of 135 H/L and two of 422 TCGA White tumors had overexpression of KIAA0100 ; the frequency difference is highly significant ( P = 0.00029, Fisher exact test).

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nominally significantP value = 0.03actually significant

Of the seven individual mutations observed in more than 2% of tumors, we observed nominally significant higher frequency of the E545K hotspot mutation in PIK3CA (13.7% vs. 7.5%, Fisher exact test P value = 0.03) and a nonsignificant trend toward higher frequency of the splice variant in GATA3 (4.8% vs. 1.9%, Fisher exact test P value = 0.07) in H/L compared with TCGA Whites (Supplementary Table S5).

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a nonsignificant trendP value = 0.07so close (0.05 < p ≤ 0.1)

7.5%, Fisher exact test P value = 0.03) and a nonsignificant trend toward higher frequency of the splice variant in GATA3 (4.8% vs. 1.9%, Fisher exact test P value = 0.07) in H/L compared with TCGA Whites (Supplementary Table S5).

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