showed a trendP < 5×10 −6
For SNPs that reached statistical significance ( P = 5.0×10 −8 /3 = 1.67×10 −8 , to account for three main tests) or showed a trend towards that threshold ( P < 5×10 −6 ), we performed stratified G×E analyses by sex, tumor site (proximal colon, distal colon, rectum), and study design.