In-Depth Mass Spectrometry Analysis Reveals the Plasma Proteomic and N-Glycoproteomic Impact of an Amish-Enriched Cardioprotective Variant in B4GALT1.

In our shotgun proteomics data, the level of ApoB, which compose LDL particles was slightly lower in minor homozygotes, and the level of apolipoprotein A1 (ApoA1) which composes HDL particles was slightly higher, in agreement with the expected trend as well as the ELISA data ( supplemental Table S3 ), these differences did not reach statistical significance (original p -values < 0.05).

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