In another study, individuals classified as Aβ-negative CU, Aβ-positive CU, Aβ-positive MCI, and Aβ-positive AD showed a trend toward longitudinal tau accumulation predominantly in Braak I–II, I–III, IV–V, and V–VI ROIs, respectively ( 25 ).
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The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework.
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