Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease.

They also reported that T-cell deficiency of Prmt5 resulted in impaired cholesterol metabolism and Ror-γt activation, leading to a severe defect in the differentiation of naïve T cells toward the Th17 phenotype in the in vitro Th cells polarization system, they also found that MOG-specific Th1 and Th17 responses were notably reduced among splenocytes, whereas T-bet+ IL-17+ Th17 cell responses did not reach statistical significance.

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