The proportions of NK cells and NKA, NKG2D and NKG2D/NKG2A expression levels, which all showed an increasing trend after prostatectomy, were higher in the stage I + II group compared with the stage III + IV group.
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NKG2A and circulating extracellular vesicles are key regulators of natural killer cell activity in prostate cancer after prostatectomy.
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The siRNAs targeting NKG2D and NKG2A showed a trend similar to that of inhibitory antibodies (Fig. 4J–L ).