Regarding the heart failure endpoint, time to first occurrence of hospitalization for heart failure, a hypothesis, was « nominally significant », HR 0.67 (0.52, 0.87), and « subgroup analysis showed that the reduced risk of HR for time to the first occurrence of hospitalization for heart failure for canagliflozin was mainly seen in those with history of heart failure at baseline ».
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Comprehensive review of SGLT2 inhibitors' efficacy through their diuretic mode of action in diabetic patients.
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