Second haploidentical stem cell transplantation (HAPLO-SCT2) after relapse from a first HAPLO-SCT in acute leukaemia-a study on behalf of the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT).

Bone Marrow Transplant · 2023 · PMC10400422 · PMID 37160941

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0800

boldest claim

The sentences

of borderline significancep = 0.053so close (0.05 < p ≤ 0.1)

Myeloablative conditioning for HAPLO-SCT2 was of borderline significance for improved LFS compared to RIC (p = 0.053), without increasing NRM.

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showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Variables that reached significance for RI were stage at HAPLO-SCT2 ( p = 0.003) and interval from HAPLO-SCT1 to relapse ( p = 0.008), while MAC showed a trend towards lower RI as compared to RIC ( p = 0.08).

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a trend towards significanceno p-value reported

Although not significant for OS/LFS, a MAC for HAPLO-SCT2 rendered a trend towards significance for lower RI and improved LFS, while it was not associated with a higher NRM.

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