Barely Significant
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The Partial M<sub>1</sub> Muscarinic Cholinergic Receptor Agonist, CDD-0102A, Differentially Modulates Glutamate Efflux in Striatal Subregions during Stereotyped Motor Behavior in the BTBR Mouse Model of Autism.

ACS Chem Neurosci · 2023 · PMC10401636 · PMID 37434313

Europe PMCDOI
1
hedged sentence
0.0650
closest p · 1.3× alpha
0.0650
boldest claim

The sentences

approached significancep = 0.065so close (0.05 < p ≤ 0.1)
Post-hoc analyses revealed that the decrease in glutamate efflux was significantly greater across the beginning 3 s of a bout in BTBR mice injected with saline compared to that of B6 mice injected with saline ( p < 0.001). CDD-0102A injection in BTBR mice led to a similar decrease in glutamate efflux during the initial second of a behavioral bout compared to that of BTBR saline-injected mice ( p > 0.05) and approached significance during second 2 ( p = 0.065), and the decrease in glutamate efflux at 3 s was significantly reduced compared to that of BTBR saline-injected mice ( p = 0.0051).

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