Loss of Pkd1 limits susceptibility to colitis and colorectal cancer.

At five weeks after tamoxifen treatment, there was a highly significant reduction in the number of tumors of mice with heterozygous or homozygous loss of Pkd1 specifically in the same cells as those with loss of Apc (e.g., not in the normal colon epithelium).

also in 132,142 other papers

However, overall, PKD1 -mutated tumors tended to be observed at earlier stages than PKD1 tumors (although the observation did not reach statistical significance due the limited number of PKD1 -mutated tumors) (Fig. 6D ).

also in 111,027 other papers