Mucolytic treatment of chronic rhinosinusitis in a murine model of primary ciliary dyskinesia.

In contrast, both TCEP- and saline-treated animals showed a highly significant increase in nasal airspace ( Figures 4B, C ; p < 0.0001; n = 29).

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Although not statistically significant, treatment with the mucolytic agent showed a clear trend toward more efficient mucus removal ( Figure 3D ), potentially by reducing the disulfide cross-links in the mucin molecules.

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