Elevated α5 integrin expression on myeloid cells in motor areas in amyotrophic lateral sclerosis is a therapeutic target.

Proc Natl Acad Sci U S A · 2023 · PMC10410747 · PMID 37523555

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Similarly, Vercelli scoring, used to assess motor phenotype in ALS mice ( 29 ), showed a trend toward better scores for α5 integrin–treated mice, with a significant difference at week 18 (corresponding to early disease stage) compared to isotype-treated mice ( SI Appendix , Fig.

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