A frequent CYP2D6 variant promotes skipping of exon 3 and reduces CYP2D6 protein expression in human liver samples.

Front Pharmacol · 2023 · PMC10412816 · PMID 37576811

Europe PMC DOI

hedged sentence

0.0820

closest p · 1.6× alpha

0.0820

boldest claim

The sentences

did not reach statistical significancep = 0.082so close (0.05 < p ≤ 0.1)

While *41 was associated with decreased full-length CYP2D6 protein, it did not reach statistical significance ( p = 0.082), in agreement with its lack of association with total CYP2D6 mRNA levels.

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