Putative malignant hyperthermia mutation Ca_V1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance.

However, the same preparations from HET mice indicated a trend to a higher equilibrium dissociation constant (lower affinity; K D = 7.7 nM) compared to either WT or HOM (5.8 and 4.2 nM, respectively) for [ 3 H]Ry binding, though the differences did not reach statistical significance (HET versus WT, p = 0.460; HET versus HOM, p = 0.104; Fig. 6 , A – D ).

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