Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.

Finally, IMC data also showed a trend towards a reduction (not significant, ns) of total macrophages in the treated tumors as shown by flow cytometry, again more evident in the viable tumor regions ( figure 6C,D and F4/80 and CD68 panels and online supplemental figure 8H ).

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We showed a highly significant enrichment in both the IOT-resistant and IOT-responsive models for CD39 + CD73 + double-expressing immune cells, when compared with secondary lymphoid organs (spleen and nodes).

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