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Efficient manufacturing and engraftment of <i>CCR5</i> gene-edited HSPCs following busulfan conditioning in nonhuman primates.

Mol Ther Methods Clin Dev · 2023 · PMC10415663 · PMID 37575091

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After 90 days post transplant, CCR5 editing in peripheral white blood cells ranged from 20% to 40% of alleles, which trended higher than HBG editing in the primed marrow/TBI cohort ( Figure 4 C) but did not reach statistical significance.

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