Pulmonary resistance is unaffected by loss of CFTR in smooth muscle with no significant changes in baseline resistance, although a nonsignificant trend of lower pulmonary resistance was noted in Cftr fl/fl ; SM-Cre mice (Fig. 2 C).
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CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity.
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Total cell counts in BAL fluid trended towards an increase in both TGFβ treated groups but did not reach statistical significance (Fig. 3 C).