Immunomodulatory Effects of Subacute Inhalation Exposure to Copper Oxide Nanoparticles in House Dust Mite-Induced Asthma.

Similarly, the percentages of antigen-experienced CD4 + T cells subsets that could be identified as specific CD4 T cell subsets in AIT-treated asthmatic mice showed highly significant increases in T H 1 ( p < 0.0001) and T H 17 ( p < 0.01) cells, while decreases were noted for antigen-experienced CD4 + T H 2 ( p < 0.0001) and Treg cells ( p < 0.0001) compared to the asthmatic mice ( Figure S5-c ).

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The sera from asthmatic mice (collected on day 52) showed a trend toward higher levels of HDM-specific IgE than the sham mice ( p = 0.16), while showing significantly higher levels of HDM-specific IgG 1 ( p < 0.05) and IgG 2a ( p < 0.05) ( Figure 3 -f).

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