Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence.

However, in immunofluorescence staining, only a trend for sortilin and p16 increases was observed, which did not reach statistical significance ( Figure 4 E), although a doubling in the number of senescent cells was observed by p16 stainings ( Figure 4 F). 3.

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